What Are Bitot Spots? Causes, Symptoms, and Treatment for Vitamin A Deficiency
What Are Bitot Spots? Causes, Symptoms, and Treatment for Vitamin A Deficiency
4 March 2025

Bitot spots are among the most significant clinical signs of vitamin A deficiency. They are mainly connected to cases of malnutrition and poor dietary intake. These are foamy, whitish patches that develop on the conjunctiva, which is a tenuous membrane covering the white part of the eye. Although they do not cause any pain at the beginning, it is a strong indication of an underlying nutritional deficiency that will go forth to cause complications such as blindness.

Given this, an understanding of the causes, symptoms, and treatment of Bitot spots gives early intervention and prevention against blindness. Therefore, this article gets deeper into the details regarding Bitot spots, trying to explain their relationship with vitamin A deficiency and what needs to be done to address such a health issue.

What are Bitot Spots?

Bitot spots are triangular, foamy, or dry patches appearing on the conjunctiva of the eye. They mostly appear on the temporal side of the eye and are associated with the keratinization of the conjunctival epithelium. These are some of the earliest clinical signs of vitamin A deficiency recognizable by health workers.

It was first described in the 19th century by a French physician named Pierre Bitot. These have now become a hallmark of hypovitaminosis A and are largely found in a great number of children, mostly in developing countries where malnutrition is very common.

Causes of Bitot Spots

The primary cause of Bitot spots is a deficiency of vitamin A, though several other factors can cause them. These include:

1. Inadequate food 

The body will lack vitamin A if the intake of the food is also deficient in the same. Vitamin A is essential for the maintenance of normal vision and immunity and maintaining the integrity of epithelial cells. Mostly, inadequate intake is because of the lack of foods rich in vitamin A, which may be lacking in the diet in some cases.

2. Malabsorption conditions 

Several medical conditions cause interference with the body's ability to absorb Vitamin A from food, namely:

  • Celiac disease
  • Crohn's disease
  • Cystic fibrosis
  • Chronic pancreatitis

3. Liver Diseases

Since it is stored in the liver, chronicity of any liver disease will lead to functional failure, including cirrhosis or viral hepatitis, hence causing a deficiency in the same.

4. Protein-Energy Malnutrition

Normally, malnourished people, especially children living in low-income regions, would more than likely be having an additional deficiency in vitamin A. It normally makes such a condition worse because it hampers transportation in the blood by the already affected vitamin.

5. Alcoholism

Chronic alcohol intake has a devastating effect on liver function. In an appreciable percentage of alcoholics, storage capacity and that of utilizing vitamin A are damaged, hence normally making them deficient in it.

Symptoms of Vitamin A Deficiency

Bitot spots are among the early symptoms of deficiency in vitamin A. Other signs are:

1. Night Blindness

A person with the earliest stages of the deficiency finds it very hard to see in dim light. It often results from the defective production of rhodopsin, which is a photosensitive pigment found on the retina.

2. Dry eyes (xerophthalmia)

Vitamin A plays a key role in keeping the eyes moist. Its deficiency results in dry eyes and irritation while increasing the risk of infections by reducing tears.

3. Corneal Ulcers and Keratomalacia

Long-term lack of vitamin A in its prolonged deficiency leads to corneal softening, ulcers, and ultimate blindness through keratomalacia.

4. Decreased Immune Function

It is of high activity in immune system function. Vitamin A deficiency leads to an increase in susceptibility to infections, especially in children, respiratory and gastrointestinal infections.

5. Skin and Hair Problems

A lack of vitamin A can cause rough and dry skin, and hair can be easily broken by impaired cell regeneration.

Diagnosis of Bitot Spots

The diagnosis of Bitot spots is based on a clinical examination of the eye by a health care provider. Other tests may be conjured for the confirmation of vitamin A deficiency.

  • Serum Vitamin A Test: This test measures how much vitamin A is in the blood.
  • Ophthalmic Examination: It aims to visualize the intensity of changes in the eyes upon other signs of xerophthalmia.
  • Dietary Assessment: By this, the patient's intake of food and level of risk for deficiency are assessed

Treatment of Bitot Spots and Vitamin A Deficiency

Treatment includes adjusting the diet and supplementation, as well as treatment for any underlying causes that might cause a decrease in absorption.

1. Vitamin A Supplementation

The best treatment is high-dose vitamin A through supplementation. WHO prescribes:

  • Children aged 6–12 months: orally, 100,000 IU of vitamin A once.
  • Children aged 12 to 59 months: 200,000 IU of Vitamin A orally every 4 to 6 months.
  • In severe cases: a second 200,000 IU dose is on days 1, 2, and 14.

2. Diet Modifications

Have rich food in vitamin A to overcome its deficiency in the long run. They are as follows:

  • Animal-based sources: Liver, eggs, dairy foods, and fish. 
  • Plants: Carrots, mangoes, dark green leafy veggies like spinach, pumpkins, and sweet potatoes, which are a rich source of beta-carotene converted into vitamin A by the body.

3. Treat the Underlying Conditions

In patients with malabsorption disorders or liver diseases, it is the primary condition that needs to be managed to have good vitamin A absorption.

4. Eye Hygiene and Care

Introducing hygiene and using artificial tears or lubricating eye drops can alleviate symptoms of dryness and irritation.

5. Public Health Interventions

In the areas where vitamin A deficiency is still a plague, these programs take on the character of the only essential reduction measures for balancing the prevalence of deficiency-related diseases: large-scale supplementation programs, food fortification, and education programs on nutrition.

Prevention of Bitot Spots and Vitamin A Deficiency

These preventive strategies are focused on improving dietary intake and also giving attention to public health interventions:

  1. Breastfeeding: Ensures, through exclusive breastfeeding for six months, that the infant acquires adequate nutrient intake, including vitamin A.
  2. Food Fortification: The staple food is fortified with vitamin A by blending it with cooking oil, milk, or flour to bring about a reduction in the rate of deficiency in an at-risk population.
  3. Education and Awareness: Educating and creating awareness about diets containing sufficient vitamin A could prevent conditions resulting from its deficiency.
  4. Routine Vitamin A Supplementation: WHO/UNICEF recommends giving children in areas identified as high-risk periodic vitamin A supplements.

Conclusion

Bitot spots are a clinical vitamin A deficiency sign and are very useful as an early warning for immediate nutritional action. Simple complications can become severe, even up to cases of blindness this is when infectious diseases emerge. Proper dietary intake and active vitamin A supplementation, together with treatment of the root health condition, will result in a positive course of the Bitot spots and their related vitamin A deficiency.

Public health initiatives, including supplementation programs and food fortification, play a vital role in reducing the prevalence of vitamin A deficiency worldwide. Awareness and education about proper nutrition are essential in preventing this avoidable health issue. You can also contact Vision Concern for any information regarding your eye health.

Frequently Asked Questions (FAQ)

1. Do Bitot spots form permanently?

No, they are reversible by proper vitamin A supplementation and improved dietary intake; however, if vitamin A deficiency advances to a certain degree, permanent loss of vision can be expected.

2. Can adults have Bitot spots?

Yes, although they are more common in children with severe vitamin A deficiency due to malabsorption disorders or chronic illnesses.

3. How long do Bitot spots take to disappear with treatment?

Improvements in Bitot spots with appropriate vitamin A supplementation generally begin within a few weeks. The time for full resolution is variable and depends on the extent of deficiency and general state of health.

4. What will happen if vitamin A deficiency is left untreated? 

Without treatment, a vitamin A deficiency can lead to progressive eye damage, night blindness, corneal ulcers, keratomalacia, and finally, total blindness. It also lowers resistance and increases the risk of infection.

Yes, we provide emergency eye care for conditions like eye injuries, sudden vision loss, and infections. If you experience any urgent eye problems, please contact us immediately, and our team will assist you in getting the care you need.

Signs to watch for include blurry vision, floaters, sudden loss of vision, eye pain, redness, or sensitivity to light. If you experience any of these symptoms, it’s important to schedule an eye exam at Vision Concern Eye Clinic as soon as possible for early diagnosis and treatment.

If you’re experiencing blurred vision, headaches, or eye strain, it may be a sign that you need glasses or contact lenses. Our eye exams will help determine whether you need corrective lenses. We’ll also discuss your options based on your lifestyle and preferences, including glasses, contacts, or even refractive surgery like LASIK.