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Anisocoria: Why Are My Pupils Different Sizes?

Anisocoria: Why Are My Pupils Different Sizes?

Published By: Vision Concern editorial team
11 November 2026
Last updated: 11 November 2026

Quick answer: Anisocoria means the two pupils are different sizes. A small difference (under about 1 mm) is common and often harmless. A new difference that comes with a droopy eyelid, double vision, severe headache, eye pain or weakness needs emergency care, because it can signal a nerve or brain problem.

Noticed this in your own eyes? Book an eye examination (NPR 400) with an optometrist at Vision Concern Lazimpat, Boudha-Tushal or Makalbari. WhatsApp +977 9841466716.

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Related service: Comprehensive eye examination (NPR 400) at Vision Concern Lazimpat, Boudha-Tushal and Makalbari.

What anisocoria means

The pupil is the black opening in the centre of the iris. Two muscles control its size: one makes it smaller in bright light and one widens it in dim light. When the two pupils differ in size, this is called anisocoria.

About one in five people have a slight, stable difference that never causes problems. This is called physiological anisocoria and the difference stays about the same in light and dark.

Common causes

  • Physiological (harmless) anisocoria
  • Eye drops or medicines, including some motion-sickness patches, inhalers and dilating drops
  • Previous eye injury or eye surgery
  • Inflammation inside the eye (iritis)
  • Adie pupil, a slowly reacting enlarged pupil
  • Horner syndrome, a small pupil with a slightly droopy lid
  • Third-nerve palsy, an enlarged pupil with droopy lid and double vision

How it is checked

An optometrist compares the pupils in bright and dim light, checks how they react, looks at eyelid position and eye movements, and asks about medicines, drops and injuries. Old photos can help show whether the difference is new.

When to get urgent care

Go to an emergency department or eye hospital the same day if unequal pupils are new and come with a droopy eyelid, double vision, severe headache, eye pain, blurred vision, neck pain, confusion, weakness or a recent head injury.

How Vision Concern can help

Vision Concern optometrists in Kathmandu can examine your eyes, record what they find for comparison, update your glasses or contact lenses, and refer you to an ophthalmologist or eye hospital when medical treatment is needed. Vision Concern does not perform surgery or injections.

Frequently asked questions

Is it normal to have one pupil slightly bigger?

Yes. A small, stable difference is common and usually harmless, especially when vision is normal and there are no other symptoms.

Can eye drops cause unequal pupils?

Yes. Dilating drops, some allergy or glaucoma drops, and contact with medicines such as scopolamine patches can change one pupil’s size for hours to days.

Should I get unequal pupils checked?

Have any new difference checked. If it comes with headache, double vision, a droopy lid or eye pain, seek emergency care rather than waiting for a routine appointment.

This guide is general information from the Vision Concern editorial team. It is not a diagnosis and does not replace an eye examination or medical advice.

Yes. Many visitors, particularly from Bangladesh and West Bengal (Kolkata), come to Nepal for cataract, retina, or other eye surgery at a hospital and also want new glasses, a general eye exam, or contact lenses at the same time, before or after their procedure. Vision Concern is an optical and eye-examination clinic, not a surgical hospital, so we work alongside hospitals such as Tilganga: we are happy to see you for glasses, contact lenses, or a routine check-up either side of your surgical treatment elsewhere.

No conversion is needed. Eyeglass prescriptions from Germany, France, the UK, the USA, China, Russia, and almost every other country use the same international format, SPH (sphere), CYL (cylinder), and AXIS, measured in diopters. Our opticians read this directly, so you can bring your prescription paper, a photo of it on your phone, or simply your current glasses, and we will use the same values. If your prescription is more than a year or two old, we recommend a quick, free re-check before we make your new pair.

Yes. Above roughly 3,000 metres, UV exposure increases sharply because of the thinner atmosphere and reflection off snow, and ordinary sunglasses (category 2-3) do not block enough UV to prevent snow blindness (photokeratitis). We recommend glacier glasses or category-4 sunglasses with side shields, and can fit these with your own prescription if needed. Vision Concern offers ZEISS polarized, UV400-certified sunglasses with prescription lenses, which we can prepare before you set off on your trek.

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